Notice of RetractionCardio-Protective Effects of Total Flavonoids from Dracocephalum moldavica L. on Acute Myocardial Ischemia/Reperfusion Injury in Rats

Notice of Retraction

After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.

We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.

The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.

The purpose of this study was to investigate the protective effect of total flavonoids from Dracocephalum moldavica L. (DML) on myocardial ischemia/reperfusion injury in isolated rat hearts. Male Wistar rats were randomly divided into three groups, Hearts were excised and attached to Langerdorff apparatus, Fluid of perfusion was Krebs-Henseleit with mixture of 95% oxygen and 5%carbondioxide. Left ventricular developed pressure (LVDP) and maximum up/down rate of left ventricular pressure (±dp/dtmax) were recorded as myocardial function by a Power Lab system. And the level of superoxide dismutase (SOD), malondialdehyde (MDA) and GSH/GSSG ratio were analyzed to determine the oxidative stress status in myocardial tissue. The level of MDA significantly decreased (P<;0.01) in DML group compared to the IR group, as well as the SOD activity (P<;0.01) and total glutathione (P<;0.05) increased the results implied that the DML has obviously protective effects in myocardial reperfusion injury.