DocumentCode
3347660
Title
Notice of Retraction
Cardio-Protective Effects of Total Flavonoids from Dracocephalum moldavica L. on Acute Myocardial Ischemia/Reperfusion Injury in Rats
Author
Ting Wang ; Wang Dong ; Wei Fu ; Ting Liu ; Bo Zhang ; Zhenhua Wang ; Qiusheng Zheng
Author_Institution
Key Lab. of Xinjiang Endemic Phytomedicine Resources, Shihezi Univ., Shihezi, China
fYear
2011
fDate
10-12 May 2011
Firstpage
1
Lastpage
3
Abstract
Notice of Retraction
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
The purpose of this study was to investigate the protective effect of total flavonoids from Dracocephalum moldavica L. (DML) on myocardial ischemia/reperfusion injury in isolated rat hearts. Male Wistar rats were randomly divided into three groups, Hearts were excised and attached to Langerdorff apparatus, Fluid of perfusion was Krebs-Henseleit with mixture of 95% oxygen and 5%carbondioxide. Left ventricular developed pressure (LVDP) and maximum up/down rate of left ventricular pressure (±dp/dtmax) were recorded as myocardial function by a Power Lab system. And the level of superoxide dismutase (SOD), malondialdehyde (MDA) and GSH/GSSG ratio were analyzed to determine the oxidative stress status in myocardial tissue. The level of MDA significantly decreased (P<;0.01) in DML group compared to the IR group, as well as the SOD activity (P<;0.01) and total glutathione (P<;0.05) increased the results implied that the DML has obviously protective effects in myocardial reperfusion injury.
After careful and considered review of the content of this paper by a duly constituted expert committee, this paper has been found to be in violation of IEEE´s Publication Principles.
We hereby retract the content of this paper. Reasonable effort should be made to remove all past references to this paper.
The presenting author of this paper has the option to appeal this decision by contacting TPII@ieee.org.
The purpose of this study was to investigate the protective effect of total flavonoids from Dracocephalum moldavica L. (DML) on myocardial ischemia/reperfusion injury in isolated rat hearts. Male Wistar rats were randomly divided into three groups, Hearts were excised and attached to Langerdorff apparatus, Fluid of perfusion was Krebs-Henseleit with mixture of 95% oxygen and 5%carbondioxide. Left ventricular developed pressure (LVDP) and maximum up/down rate of left ventricular pressure (±dp/dtmax) were recorded as myocardial function by a Power Lab system. And the level of superoxide dismutase (SOD), malondialdehyde (MDA) and GSH/GSSG ratio were analyzed to determine the oxidative stress status in myocardial tissue. The level of MDA significantly decreased (P<;0.01) in DML group compared to the IR group, as well as the SOD activity (P<;0.01) and total glutathione (P<;0.05) increased the results implied that the DML has obviously protective effects in myocardial reperfusion injury.
Keywords
biochemistry; biological tissues; blood; cardiology; cellular biophysics; injuries; organic compounds; Dracocephalum moldavica L; GSH-GSSG ratio; Krebs-Henseleit perfusion fluid; LVDP; Langerdorff apparatus; Wistar rats; acute myocardial ischemia-reperfusion injury; cardioprotective effects; left ventricular developed pressure; malondialdehyde level; oxidative stress status; rat model; superoxide dismutase level; total flavonoids; Chemicals; Heart; Injuries; Myocardium; Rats; Stress;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Biomedical Engineering, (iCBBE) 2011 5th International Conference on
Conference_Location
Wuhan
ISSN
2151-7614
Print_ISBN
978-1-4244-5088-6
Type
conf
DOI
10.1109/icbbe.2011.5781649
Filename
5781649
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