Title :
Modeling the cellular kinetics of the antiviral agents PMEA and PMPA
Author :
Argenio, David Z D ; Rodman, John H. ; Robbins, Biran L. ; Fridland, Arnold
Author_Institution :
Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA, USA
fDate :
31 Oct-3 Nov 1996
Abstract :
The cellular kinetics of the antiviral nucleoside analogs PMEA and PMPA were modeled using intracellular measurements of the phosphonate analogs and their mono- and diphosphate derivatives, obtained following systemic administration of the parent compounds in monkeys. By decoupling the systemic disposition processes from the cellular events, a model describing the kinetics in lymphoid and red blood cells was developed
Keywords :
cellular biophysics; organic compounds; physiological models; PMEA; PMPA; antiviral agents; antiviral nucleoside analogs; cellular events; cellular kinetics modeling; diphosphate derivatives; intracellular measurements; lymphoid cells; monkeys; monophosphate derivatives; parent compounds; phosphonate analogs; red blood cells; systemic administration; systemic disposition processes; Animals; Biochemistry; Cells (biology); DNA; In vitro; Kinetic theory; Plasma applications; Plasma measurements; Red blood cells; Viruses (medical);
Conference_Titel :
Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE
Conference_Location :
Amsterdam
Print_ISBN :
0-7803-3811-1
DOI :
10.1109/IEMBS.1996.646312
