Modeling the cellular kinetics of the antiviral agents PMEA and PMPA

Author

Argenio, David Z D ; Rodman, John H. ; Robbins, Biran L. ; Fridland, Arnold

Author_Institution

Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA, USA

Volume

5

fYear

1996

fDate

31 Oct-3 Nov 1996

Firstpage

1903

Abstract

The cellular kinetics of the antiviral nucleoside analogs PMEA and PMPA were modeled using intracellular measurements of the phosphonate analogs and their mono- and diphosphate derivatives, obtained following systemic administration of the parent compounds in monkeys. By decoupling the systemic disposition processes from the cellular events, a model describing the kinetics in lymphoid and red blood cells was developed

Keywords

cellular biophysics; organic compounds; physiological models; PMEA; PMPA; antiviral agents; antiviral nucleoside analogs; cellular events; cellular kinetics modeling; diphosphate derivatives; intracellular measurements; lymphoid cells; monkeys; monophosphate derivatives; parent compounds; phosphonate analogs; red blood cells; systemic administration; systemic disposition processes; Animals; Biochemistry; Cells (biology); DNA; In vitro; Kinetic theory; Plasma applications; Plasma measurements; Red blood cells; Viruses (medical);

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1996. Bridging Disciplines for Biomedicine. Proceedings of the 18th Annual International Conference of the IEEE

Conference_Location

Amsterdam

Print_ISBN

0-7803-3811-1

Type

conf

DOI

10.1109/IEMBS.1996.646312

Filename

646312