Demonstration of molecular upconvertors

Author

Faris, G.W. ; Dyer, M.J.

Author_Institution

Molecular Phys. Lab., SRI Int., Menlo Park, CA, USA

fYear

1992

fDate

23-28 May 1992

Firstpage

262

Lastpage

263

Abstract

Summary form only given. We report on a new type of optical reporter suitable for in vivo and in vitro diagnostics: molecular upconvertors. These reporters consist of single lanthanide ions held by a chelating ligand. These reporters have properties that are advantageous for use in biomedical diagnostics. These reporters have many of the properties of upconverting phosphor reporters-no autofluorescence, multiplexing capabilities, no photobleaching, and excitation with compact and low power diode lasers-but in a molecular scale reporter.

Keywords

fluorescence spectroscopy; laser applications in medicine; patient diagnosis; phosphors; biomedical diagnostics; chelating ligand; in vitro diagnostics; in vivo diagnostics; low power diode lasers; molecular scale reporter; molecular upconvertors; multiplexing capabilities; optical reporter; single lanthanide ions; upconverting phosphors; Biomedical imaging; Biomedical optical imaging; Coherence; High speed optical techniques; Humans; In vivo; Medical diagnostic imaging; Neoplasms; Optical distortion; Optical imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Quantum Electronics and Laser Science Conference, 1999. QELS '99. Technical Digest. Summaries of Papers Presented at the

Conference_Location

Baltimore, MD, USA

Print_ISBN

1-55752-576-X

Type

conf

DOI

10.1109/QELS.1999.807647

Filename

807647