Inhibitory effect of subthreshold high-frequency stimuli: a computer simulation study

Author

Sáiz, J.F. ; Ferrero, J.M., Jr. ; Chorro, F.J. ; Monserrat, M. ; López-Merino, V. ; Ferrero, J.M. ; Thakor, N.V.

Author_Institution

Lab. Integrado Bioingenieria, Univ. Politecnica de Valencia, Spain

Volume

1

fYear

1997

fDate

30 Oct-2 Nov 1997

Firstpage

213

Abstract

A computer model of the ventricular action potential was used to study the effect of trains of subthreshold high-frequency stimuli (TSc) on the prolongation of the effective refractory period (ERP). A zone of ventricular tissue is simulated by a one-dimensional structure. Trains of subthreshold high-frequency stimuli, at different frequencies were applied between the two suprathreshold pulses S1 and S2 and the ERP was measured as a function of TSc frequency. Our simulation results are in agreement with the experimental results. The results suggest that the prolongation of recovery from inactivation of the fast Na⁺ current could be partially responsible for the prolongation of the ERP.

Keywords

bioelectric potentials; biological tissues; biomembrane transport; patient treatment; physiological models; channel activation kinetics; computer model; computer simulation; effective refractory period; fast Na⁺ current; inhibitory effect; one-dimensional structure; prolongation of recovery; stimuli trains; subthreshold high-frequency stimuli; suprathreshold pulses; ventricular action potential; zone of ventricular tissue; Biomedical computing; Biomedical engineering; Cardiology; Computer simulation; Delay; Enterprise resource planning; Frequency; Hospitals; Laboratories; Pulse measurements;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-4262-3

Type

conf

DOI

10.1109/IEMBS.1997.754507

Filename

754507