Title :
A model of sympathetic neural control of cardiac pacemaker activity
Author :
Dokos, Socrates ; Celler, Branko G. ; Lovell, Nigel H.
Author_Institution :
Sch. of Electr. Eng., New South Wales Univ., Kensington, NSW, Australia
fDate :
30 Oct-2 Nov 1997
Abstract :
We have modified an existing mathematical model of single cell rabbit sinoatrial node activity to incorporate the dynamic modulation of its membrane currents by sympathetic neural stimulation. The resulting model was able to reproduce the experimentally observed changes in action potential waveform as well as the time course of the positive chronotropic response following sympathetic stimulation.
Keywords :
bioelectric potentials; biomembrane transport; cardiology; neurophysiology; physiological models; action potential waveform; cardiac pacemaker activity; dynamic modulation; ionic mechanisms; membrane currents; modified mathematical model; positive chronotropic response; single cell rabbit sinoatrial node activity; sympathetic neural control; sympathetic neural stimulation; time course; Australia; Biomedical engineering; Biomembranes; Delay; Electronic mail; Kinetic theory; Laboratories; Mathematical model; Pacemakers; Rabbits;
Conference_Titel :
Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE
Print_ISBN :
0-7803-4262-3
DOI :
10.1109/IEMBS.1997.754509
