A model of sympathetic neural control of cardiac pacemaker activity

Author

Dokos, Socrates ; Celler, Branko G. ; Lovell, Nigel H.

Author_Institution

Sch. of Electr. Eng., New South Wales Univ., Kensington, NSW, Australia

Volume

1

fYear

1997

fDate

30 Oct-2 Nov 1997

Firstpage

220

Abstract

We have modified an existing mathematical model of single cell rabbit sinoatrial node activity to incorporate the dynamic modulation of its membrane currents by sympathetic neural stimulation. The resulting model was able to reproduce the experimentally observed changes in action potential waveform as well as the time course of the positive chronotropic response following sympathetic stimulation.

Keywords

bioelectric potentials; biomembrane transport; cardiology; neurophysiology; physiological models; action potential waveform; cardiac pacemaker activity; dynamic modulation; ionic mechanisms; membrane currents; modified mathematical model; positive chronotropic response; single cell rabbit sinoatrial node activity; sympathetic neural control; sympathetic neural stimulation; time course; Australia; Biomedical engineering; Biomembranes; Delay; Electronic mail; Kinetic theory; Laboratories; Mathematical model; Pacemakers; Rabbits;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-4262-3

Type

conf

DOI

10.1109/IEMBS.1997.754509

Filename

754509