Title :
Simulation study of cardiac compensatory mechanism during left ventricular regional ischemia
Author :
Zhou, Xiaoqiang ; Bai, Jing ; Zhao, Bing ; Shi, Xin
Author_Institution :
Tsinghua University, Beijing, China
fDate :
Oct. 30 1997-Nov. 2 1997
Abstract :
In order to investigate the mechanism of cardiac compensation from the level of microscope, we have developed a model of regionally ischemic left ventricle based on muscle fiber structure and mechanical properties of sarcomere, and incorporated it into a circulatory model established by us previously. Using the model, some simulation experiments related to myocardial ischemia and cardiac compensation have been performed. The simulation results suggest when regional ischemia of the left ventricle (LV) results in cardiac insdciency, the myocardium of the normal region has certain ability to increase its contractility to maintain a normal cardiac function
Keywords :
biomechanics; cardiology; mechanical properties; muscle; physiological models; cardiac biomechanics; cardiac compensatory mechanism; cardiac insufficiency; circulatory model; left ventricular regional ischemia; muscle fiber structure; normal region myocardium; sarcomere mechanical properties; simulation experiments; Cardiology; Computer simulation; Equations; Ischemic pain; Mechanical factors; Microscopy; Muscles; Myocardium; Solid modeling; Stress; compensation; left ventricular model; regonal ischemia; sarcomere mechanics;
Conference_Titel :
Engineering in Medicine and Biology Society, 1997. Proceedings of the 19th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL, USA
Print_ISBN :
0-7803-4262-3
DOI :
10.1109/IEMBS.1997.754515
