Two EEG derived parameters for the measurement of the effects caused by propofol on sedation

Two parameters to measure propofol´s sedation effect on the EEG signal are presented. One parameter is based on a wavelet multiresolution decomposition that allows spectral analysis on each detail. The other parameter is based on cross spectrum analysis that underlines similar frequency phenomena that appear in two different EEG epochs. Both parameters were compared with the spectral edge that has been widely used to measure anesthetic induced changes on the EEG. The two parameters could be described as a sigmoidal concentration-response relationship in all real EEG signals. The results suggest that these parameters can be useful for propofol sedation monitoring, pharmacodynamical modeling and closed-loop propofol sedation control systems