Design and Verification of Ultra Low Current Mode Amplifier Aiming at Biosensor Applications

Author

Zhang, Lei ; Yu, Zhiping ; He, Xiangqing

Author_Institution

Tsinghua Univ., Beijing

fYear

2007

fDate

11-14 Dec. 2007

Firstpage

1304

Lastpage

1307

Abstract

Recently, along with the booming of research and production of CMOS Integrated Bio-sensing System (IBS), ultra low current mode amplifier which serves for biosensor signal pre-amplification implemented in modern CMOS technology is in high demand in areas like ultra low bio-current analysis and detection, DNA probing and surveying systems and etc. In this paper, a novel Current Mode Pre-amplifier (CMPA) module has been presented and verified in SMIC 0.18Â¿m CMOS process by elaborately considering gain, bandwidth, noise, and mismatch. The proposed CMPA solved the noise, bandwidth, and current headroom dilemma in the reported works, and can completely satisfy the specifications of IBS and stably provide a current gain of 20dB, 3dB band width of 7.03kHz and input dynamic range of 20bit, with only 1nA of DC quiescent current, while the input offset current and noise current are less than 16.0pA and 4.67pArms, respectively.

Keywords

CMOS integrated circuits; biosensors; current-mode circuits; preamplifiers; CMOS integrated biosensing system; DNA probing; SMIC; biosensor signal preamplification; current headroom dilemma; current mode pre-amplifier module; surveying systems; ultra low biocurrent analysis; Bandwidth; Biosensors; CMOS process; Current mode circuits; DNA; Fluctuations; Mirrors; Preamplifiers; Sensor arrays; Voltage; Current Mode Preamplifier (CMPA); Integrated Bio-sensing System (IBS); Mismatch; Noise; Subthreshold;

fLanguage

English

Publisher

ieee

Conference_Titel

Electronics, Circuits and Systems, 2007. ICECS 2007. 14th IEEE International Conference on

Conference_Location

Marrakech

Print_ISBN

978-1-4244-1377-5

Electronic_ISBN

978-1-4244-1378-2

Type

conf

DOI

10.1109/ICECS.2007.4511237

Filename

4511237