Towards the Formation of Neuro-Transistor Artificial Chemical Synapse

Author

Goykhman, I. ; Korbakov, N. ; Bartic, C. ; Borghs, G. ; Spira, M.E. ; Shappir, J. ; Yitzchaik, S.

Author_Institution

Hebrew Univ. of Jerusalem, Jerusalem

fYear

2007

fDate

10-14 June 2007

Firstpage

103

Lastpage

106

Abstract

Highly sensitive biosensor for detection of acetylcholine (ACh) and competitive acetylcholinesterase (AChE) inhibitor, eserine, is investigated. Peculiar microelectronic configuration of an ion-sensitive field-effect transistor (ISFET) in addition to a right choice of the pH-transducing nano layers allows recording a response of the enzyme-modified ISFET (EnFET) to a wide range of ACh concentrations. We demonstrate a remarkable improvement of at least three orders of magnitude in dose response to ACh. Described bioelectronic system reveals clear response, when the catalytic activity of the immobilized AChE is inhibited in a reversible manner by eserine, competitive inhibitor of AChE.

Keywords

biomedical electronics; biosensors; chemical sensors; ion sensitive field effect transistors; acetylcholine detection; artificial chemical synapse; bioelectronic system; competitive acetylcholinesterase inhibitor; enzyme-modified ISFET; eserine; highly sensitive biosensor; ion-sensitive field-effect transistor; neuro-transistor; Biochemistry; Biomembranes; Biosensors; Chemicals; Degradation; Electrodes; FETs; Inhibitors; Microelectronics; Neurotransmitters; Acetylcholinesterase (AChE); EnFET; Enzyme inhibitor sensing; Neurotransmitter sensing;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International

Conference_Location

Lyon

Print_ISBN

1-4244-0842-3

Electronic_ISBN

1-4244-0842-3

Type

conf

DOI

10.1109/SENSOR.2007.4300082

Filename

4300082