Title :
Towards the Formation of Neuro-Transistor Artificial Chemical Synapse
Author :
Goykhman, I. ; Korbakov, N. ; Bartic, C. ; Borghs, G. ; Spira, M.E. ; Shappir, J. ; Yitzchaik, S.
Author_Institution :
Hebrew Univ. of Jerusalem, Jerusalem
Abstract :
Highly sensitive biosensor for detection of acetylcholine (ACh) and competitive acetylcholinesterase (AChE) inhibitor, eserine, is investigated. Peculiar microelectronic configuration of an ion-sensitive field-effect transistor (ISFET) in addition to a right choice of the pH-transducing nano layers allows recording a response of the enzyme-modified ISFET (EnFET) to a wide range of ACh concentrations. We demonstrate a remarkable improvement of at least three orders of magnitude in dose response to ACh. Described bioelectronic system reveals clear response, when the catalytic activity of the immobilized AChE is inhibited in a reversible manner by eserine, competitive inhibitor of AChE.
Keywords :
biomedical electronics; biosensors; chemical sensors; ion sensitive field effect transistors; acetylcholine detection; artificial chemical synapse; bioelectronic system; competitive acetylcholinesterase inhibitor; enzyme-modified ISFET; eserine; highly sensitive biosensor; ion-sensitive field-effect transistor; neuro-transistor; Biochemistry; Biomembranes; Biosensors; Chemicals; Degradation; Electrodes; FETs; Inhibitors; Microelectronics; Neurotransmitters; Acetylcholinesterase (AChE); EnFET; Enzyme inhibitor sensing; Neurotransmitter sensing;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International
Conference_Location :
Lyon
Print_ISBN :
1-4244-0842-3
Electronic_ISBN :
1-4244-0842-3
DOI :
10.1109/SENSOR.2007.4300082
