Towards a Fully-Integrated CMOS-Based in VIVO Neural Imaging and Interface Device

We are developing a CMOS device with integrated imaging array, electrical stimulus electrodes and chemical delivery for neural imaging and interfacing. Our aim is to perform functional imaging deep inside the mouse hippocampus at the molecular level. The device has an irregular front shape to minimize injury during insertion into the brain. Four electrodes are embedded strategically on the image array for electrical interface. A special technique is developed to package the device for in vivo fluorescence imaging and interfacing. Fluorescence imaging has been verified in vitro using a brain phantom, and electrical stimulation capability of the embedded electrodes is confirmed by impedance tests in buffered saline. Using the device, we have successful performed stimulation of the Schaffer collateral in vivo.