In-Droplet Magnetic Beads Concentration and Separation for Digital Microfluidics

Author

Wang, Yi Zhong ; Zhao, Yuejun ; Cho, Sung Kwon

Author_Institution

Univ. of Pittsburgh, Pittsburgh

fYear

2007

fDate

10-14 June 2007

Firstpage

711

Lastpage

714

Abstract

This paper describes highly efficient in-droplet particle concentrations/separations (over 91% in efficiency), where magnetic particles are concentrated/separated within a droplet by applying a magnetic field and a subsequent EWOD (electro wetting-on-dielectric) actuation physically splits a magnetic particle-rich region into an individual droplet. This in-droplet method will provide a new functionality of separation/concentration for digital (droplet-based) microfluidics, possibly allowing use of many magnetic-particles-based bio assays in digital microfluidics.

Keywords

bioMEMS; drops; electromagnets; magnetic particles; magnetic separation; microfluidics; bio assays; digital microfluidics; droplet-based microfluidics; electro wetting-on-dielectric actuation; in-droplet magnetic bead concentration; in-droplet magnetic bead separation; magnetic particle-rich region; magnetic particles; Electrokinetics; Immune system; Magnetic fields; Magnetic particles; Magnetic separation; Mechanical engineering; Microchannel; Microfluidics; Permanent magnets; Surface resistance; Concentration; EWOD; Magnetic Beads; Separation;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International

Conference_Location

Lyon

Print_ISBN

1-4244-0842-3

Electronic_ISBN

1-4244-0842-3

Type

conf

DOI

10.1109/SENSOR.2007.4300229

Filename

4300229