A study of effect of some drugs on the free-radicals processes in vitro

Author

Hadjimitova, V. ; Traykov, T. ; Goliysky, V. ; Karabacheva, Sv ; Ribarov, St

Author_Institution

Med. Univ., Sofia, Bulgaria

fYear

2000

fDate

2000

Firstpage

30

Abstract

Summary form only given. The search for new antioxidant agents is very important for the prevention and treatment of many chronic and degenerative diseases. The purpose of this study is to investigate the antioxidant activity of some drugs: Chloropromazine, Promethazine, Captopril, Cimetidine. The study was performed on a model lipid system at concentrations of 0.1-100 μmol/l. The results from TBA-test show that the phenothiazine derivatives have an antioxidant effect more pronounced than Cimetidine and Captopril. These results correlated well with the inhibition of Fe²⁺-induced chemiluminescence at the same model system. The chemiluminescent and photometric (NBT-test) registration of superoxide radicals generated in the system xantine-xantine oxydase indicates that the phenotiazine derivatives are good scavengers which partially explains their strong antioxidant properties

Keywords

biochemistry; biological techniques; chemiluminescence; free radicals; medicine; patient treatment; photometry; Captopril; Chloropromazine; Cimetidine; Fe; Fe2+-induced chemiluminescence; Promethazine; TBA-test; antioxidant activity; antioxidant agents; disease prevention; disease treatment; in vitro free-radicals processes; model lipid system; phenothiazine derivatives; photometric registration; superoxide radicals; xantine-xantine oxydase system; Biophysics; Degenerative diseases; Drugs; In vitro; Lipidomics; Medical treatment; Photometry; Physics;

fLanguage

English

Publisher

ieee

Conference_Titel

Applied Electromagnetism, 2000. Proceedings of the Second International Symposium of Trans Black Sea Region on

Conference_Location

Xanthi

Print_ISBN

0-7803-6428-7

Type

conf

DOI

10.1109/AEM.2000.943193

Filename

943193