Fabrication and Packaging of Nanoporous Membrane Chips for Label-Free Ion-Channel Transducer Based Biosensor

Author

Agache, V. ; Sauter, F. ; Pudda, C. ; Blanc, R. ; Chabrol, C. ; Caillat, P. ; Plenat, T. ; Agasoster, A. Varnier ; Ghenim, L. ; Fuchs, A.

Author_Institution

CEA-LETI, Grenoble

fYear

2007

fDate

10-14 June 2007

Firstpage

819

Lastpage

822

Abstract

This paper relates to a new architecture of label-free Ion channel based biosensors. The biochips are composed of nanoaperture arrays etched in a free-standing silicon nitride (Si₃N₄) supporting membrane. These membranes should be covered lately by a lipid bilayer which hosts bioengineered protein receptors-gated ion channels. This protein complex is used to convert specific binding events with target molecules into an electrical signal. This paper is focusing on the fabrication and packaging of the device.

Keywords

biomembrane transport; biosensors; membranes; nanoporous materials; proteins; silicon compounds; bioengineered protein receptors-gated ion channels; biosensor; free-standing silicon nitride; label- free ion-channel transducer; lipid bilayer; nanoaperture arrays; nanoporous membrane chips; specific binding events; Biomembranes; Biosensors; Etching; Fabrication; Lipidomics; Nanoporous materials; Packaging; Proteins; Silicon; Transducers; lipid bilayer; nanoporous membrane chip; on channel based biosensors;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International

Conference_Location

Lyon

Print_ISBN

1-4244-0842-3

Electronic_ISBN

1-4244-0842-3

Type

conf

DOI

10.1109/SENSOR.2007.4300256

Filename

4300256