Title :
Cell-Based Microfluidic Biochip for Electrochemical Real-Time Monitoring of Glucose and Oxygen
Author :
Rodrigues, N. Pereira ; Kimura, H. ; Sakai, Y. ; Fujii, T.
Author_Institution :
Univ. of Tokyo, Tokyo
Abstract :
In this study, we developed a new cell-based biochip dedicated to the real-time and on-line monitoring of transient effluxes of glucose and oxygen. This microfluidic device "on a chip" will therefore be dedicated and realize a complete, precise and real-time monitoring of the composition and modulation of cell medium. The microdevice is composed of arrays of amperometric microsensors integrated in the inlet and the outlet of a PDMS cell chamber. First results dedicated to glucose and oxygen calibration in the dynamic conditions of liquid flow showed good performances of the integrated microsensors in terms of linearity of response and sensitivity of detection in a physiological buffer medium.
Keywords :
amperometric sensors; electrochemical analysis; microfluidics; microsensors; monitoring; PDMS cell chamber; amperometric microsensors; electrochemical real-time monitoring; glucose; microfluidic biochip; oxygen; physiological buffer; Biomedical measurements; Biomedical monitoring; Biosensors; Chemical and biological sensors; Electrodes; Fluid flow; Microfluidics; Microsensors; Oxygen; Sugar; PDMS microfluidic biochip; glucose; integrated amperometric microsensors; oxygen;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International
Conference_Location :
Lyon
Print_ISBN :
1-4244-0842-3
Electronic_ISBN :
1-4244-0842-3
DOI :
10.1109/SENSOR.2007.4300262
