Bio-Microelectronic Information Processing Device Consisting of Natural Neurons on a CMOS Microsystem

Author

Hafizovic, S. ; Heer, F. ; Frey, U. ; Ugniwenko, T. ; Blau, A. ; Ziegler, C. ; Hierlemann, A.

Author_Institution

ETH Zurich, Zurich

fYear

2007

fDate

10-14 June 2007

Firstpage

1223

Lastpage

1226

Abstract

We report on the system integration of a CMOS chip that is capable of bidirectionally communicating (stimulation and recording) with electrogenic cells such as neurons or cardiomyocytes, and that is targeted at investigating electrical signal propagation within cellular networks in vitro. Experiments including the stimulation of neurons with two different spatio-temporal patterns and the recording of the triggered spiking activity have been carried out. The neuronal response patterns have been successfully classified (83% correct classifications) with respect to the different stimulation patterns.

Keywords

CMOS integrated circuits; bioelectric potentials; microelectrodes; neurophysiology; CMOS microsystem; biomicroelectronic information processing device; cardiomyocytes; cellular networks; electrical signal propagation; electrogenic cells; neuronal response patterns; spiking activity; Actuators; CMOS process; Cardiology; Electrodes; Event detection; Information processing; Microelectrodes; Neurons; Sensor arrays; Solid state circuits; CMOS; extracellular recording; microelectrode array; neurons;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International

Conference_Location

Lyon

Print_ISBN

1-4244-0842-3

Electronic_ISBN

1-4244-0842-3

Type

conf

DOI

10.1109/SENSOR.2007.4300357

Filename

4300357