Localization of site of origin of reentrant arrhythmia from bspms by means of a heart-model-based approach

We have developed a model-based imaging approach to inversely estimate the site of origin of reentrant arrhythmia from body su$ace potential maps (BSPM), with the aid of an ion-channel-level cardiac model. The reentry was successfully simulated and maintained. in the cardiac model, and the simulated ECG waveforms over the body sutj5ace corresponding to a mainrained reentry have evident characteristics of ventricular tachycardia. The present simulation results show that the present inverse imaging approach achieved an average localization error of about 1.5 mm when 5% Gaussian white noise was added ro the BSPMs. This pilot simularion study suggests the feasibiliiy of the modelbased imaging approach in localizing the site of origin of reentrant arrhythmias from noninvasive BSPMs.