Title :
Liquid-Phase Biochemical Sensing with Disk-Type Resonant Microsensor
Author :
Seo, Jae H. ; Betancor, Lorena ; Demirci, Kemal S. ; Byun, Albert ; Spain, Jim ; Brand, Oliver
Author_Institution :
Georgia Inst. of Technol., Atlanta
Abstract :
The application of a resonant microsensor platform based on disk-type microstructures vibrating in an in-plane resonance mode for biochemical sensing in liquid environment is described. Based on the measured short-term frequency stabilities of 1.1 10-8 in air and 2.3 10-6 in water, low femtogram and sub-picogram detection limits can be achieved in air and in liquid, respectively. The feasibility of liquid-phase biosensing using the disk resonators is demonstrated experimentally by detecting anti-beta-galactosidase antibody using covalently immobilized beta-galactosidase enzyme.
Keywords :
biochemistry; chemical sensors; microsensors; anti-beta-galactosidase antibody; disk-type resonant microsensor; frequency stabilities; liquid-phase biochemical sensing; liquid-phase biosensing; Biochemistry; Biosensors; Chemical and biological sensors; Frequency measurement; Mechanical sensors; Microsensors; Microstructure; Resonance; Resonant frequency; Stability; Biosensor; Mass-sensitive sensor; Resonant sensor; Ã\x9f-galactosidase enzyme;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International
Conference_Location :
Lyon
Print_ISBN :
1-4244-0842-3
Electronic_ISBN :
1-4244-0842-3
DOI :
10.1109/SENSOR.2007.4300488
