DocumentCode :
3379107
Title :
Fabrication of Cell-Encapsulated Microfiber using Microfluidic Channel
Author :
Kim, B. ; Choi, W.S. ; Kim, Intae ; Kim, S.-W. ; Kim, J.S. ; Lim, Geunbae
Author_Institution :
Pohang Univ. of Sci. & Technol., Pohang
fYear :
2007
fDate :
10-14 June 2007
Firstpage :
1797
Lastpage :
1800
Abstract :
In this research, we propose a novel method to fabricate a scaffold for tissue engineering which can overcome the limitations of traditional approaches. The alginate solution was gelled to form a cell- encapsulated alginate microfiber by the diffusion of gelation ion from the cross-linker solution and ejected from the outlet of microfluidic channel to the reservoir. The diameter of the fabricated microfiber can be controlled by the flow rate ratio of the two solutions. Moreover, this method, which has no cell seeding step, eliminates the possibility of loss of cells and the problems related with distribution of cells. We also show the feasibility of the alginate microfiber as a scaffold for cartilage.
Keywords :
microfluidics; tissue engineering; cell-encapsulated alginate microfiber; cross-linker solution; gelation ion diffusion; microfluidic channel; tissue engineering; Biological materials; Fabrication; Hospitals; In vitro; Mechanical engineering; Microfluidics; Micromechanical devices; Orthopedic surgery; Reservoirs; Tissue engineering; MEMS; alginate; chondrocyte; microfiber; microfluidic channel; scaffold;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2007. TRANSDUCERS 2007. International
Conference_Location :
Lyon
Print_ISBN :
1-4244-0842-3
Electronic_ISBN :
1-4244-0842-3
Type :
conf
DOI :
10.1109/SENSOR.2007.4300503
Filename :
4300503
Link To Document :
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