Title :
The expression of MGMT and ErbB2 in human glioma
Author :
Chun-ming, Sun ; Zhi-min, Wang ; Shi-ying, Zheng ; Qi-nian, Xu ; Shi-ming, Zhang ; Dai, Zhou
Author_Institution :
Dept. of Neurosurg., Soochow Univ., Suzhou, China
Abstract :
This study was comparison of MGMT and ERBB2 expression in human gliomas. RT-PCR method was used to determine the mRNA levels of MGMT and ErbB2 gene in 42 clinical glioma specimens,There was significant concordance between the expression of MGMT and ErbB2 (p < 0.01). MGMT and ErbB are highly remarkably related each other. The results suggest that there may be in relationship among MGMT and ErbB2 expression in human gliomas which affect DNA repair resulting in drug resistance.
Keywords :
DNA; cellular biophysics; drugs; genetics; molecular biophysics; patient treatment; proteomics; tumours; DNA repair; ErbB2; MGMT; RT-PCR method; drug resistance; gene; human glioma; mRNA levels; Biopsy; DNA; Drugs; Hospitals; Humans; Immune system; Medical treatment; Neoplasms; Neurosurgery; RNA; Drug-resistance gene; Glioma; RT-PCR;
Conference_Titel :
BioMedical Information Engineering, 2009. FBIE 2009. International Conference on Future
Conference_Location :
Sanya
Print_ISBN :
978-1-4244-4690-2
Electronic_ISBN :
978-1-4244-4692-6
DOI :
10.1109/FBIE.2009.5405896
