DocumentCode
3379934
Title
The expression of MGMT and ErbB2 in human glioma
Author
Chun-ming, Sun ; Zhi-min, Wang ; Shi-ying, Zheng ; Qi-nian, Xu ; Shi-ming, Zhang ; Dai, Zhou
Author_Institution
Dept. of Neurosurg., Soochow Univ., Suzhou, China
fYear
2009
fDate
13-14 Dec. 2009
Firstpage
253
Lastpage
255
Abstract
This study was comparison of MGMT and ERBB2 expression in human gliomas. RT-PCR method was used to determine the mRNA levels of MGMT and ErbB2 gene in 42 clinical glioma specimens,There was significant concordance between the expression of MGMT and ErbB2 (p < 0.01). MGMT and ErbB are highly remarkably related each other. The results suggest that there may be in relationship among MGMT and ErbB2 expression in human gliomas which affect DNA repair resulting in drug resistance.
Keywords
DNA; cellular biophysics; drugs; genetics; molecular biophysics; patient treatment; proteomics; tumours; DNA repair; ErbB2; MGMT; RT-PCR method; drug resistance; gene; human glioma; mRNA levels; Biopsy; DNA; Drugs; Hospitals; Humans; Immune system; Medical treatment; Neoplasms; Neurosurgery; RNA; Drug-resistance gene; Glioma; RT-PCR;
fLanguage
English
Publisher
ieee
Conference_Titel
BioMedical Information Engineering, 2009. FBIE 2009. International Conference on Future
Conference_Location
Sanya
Print_ISBN
978-1-4244-4690-2
Electronic_ISBN
978-1-4244-4692-6
Type
conf
DOI
10.1109/FBIE.2009.5405896
Filename
5405896
Link To Document