High sensitivity potentiostat system for sub-micron bio-sensors impedance measurements

Author

Carminati, Marco ; Ferrari, Giorgio ; Sampietro, Marco

Author_Institution

Dipt. di Elettron. e Inf., Politec. di Milano, Milano

fYear

2008

fDate

Aug. 31 2008-Sept. 3 2008

Firstpage

750

Lastpage

753

Abstract

The design and experimental characterization of a potentiostat system based on a novel modular architecture are illustrated. This instrument enables three amperometric measurements in liquid (cyclic voltammetry, electrochemical impedance spectroscopy and impedance tracking in time domain) on interfacial systems whose dimensions can range from the millimeter down to the sub-micrometric scale. In particular the system is aimed at the realization of biosensors based on the impedimetric detection of conformational changes of macromolecular biochemical transducers. To achieve high resolution (attoFarad in capacitance and TeraOhm in resistance) over a wide bandwidth (DC - 1 MHz) an integrator/differentiator front-end has been designed along with all the analog circuitry and software for numerical processing of acquired data.

Keywords

biomedical transducers; biosensors; electric impedance measurement; electrochemical impedance spectroscopy; microsensors; voltammetry (chemical analysis); amperometric measurements; bio-sensors; cyclic voltammetry; electrochemical impedance spectroscopy; high sensitivity potentiostat system; impedance measurements; impedance tracking; macromolecular biochemical transducers; time domain; Bandwidth; Biosensors; Capacitance; Chemical transducers; Circuits; Electrochemical impedance spectroscopy; Immune system; Impedance measurement; Instruments; Time measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Electronics, Circuits and Systems, 2008. ICECS 2008. 15th IEEE International Conference on

Conference_Location

St. Julien´s

Print_ISBN

978-1-4244-2181-7

Electronic_ISBN

978-1-4244-2182-4

Type

conf

DOI

10.1109/ICECS.2008.4674962

Filename

4674962