• DocumentCode
    3401925
  • Title

    Interaction between O2-Hb kinetics and the Fahraeus effect

  • Author

    Ye, Guo-Fan ; Buerk, Donald G. ; Ye, Lei ; Jaron, Dov

  • Author_Institution
    Biomed. Eng. & Sci. Inst., Drexel Univ., Philadelphia, PA, USA
  • Volume
    2
  • fYear
    1995
  • fDate
    20-23 Sep 1995
  • Firstpage
    1507
  • Abstract
    The influence of O2-Hb kinetics and the Fahraeus effect on gas transport in the microcirculation was investigated in the steady state using a multicompartmental model for O2-CO2 coupled transport in the cat brain microcirculation. Results suggest that the influence of O2-Hb reaction kinetics on oxygen transport is characterized by two major features: the difference-at the same Po2-between the actual capillary O2-Hb saturation and the equilibrium O2-Hb saturation, and an increase in the value of venous Po2 predicted by the model. The Fahraeus effect results in a Po2 increase in the vein and venules and a Po2 decrease in the tissue and arterioles. The two mechanisms enhance each other. Their interaction is more significant during ischemia
  • Keywords
    biotransport; brain models; haemorheology; oxygen; physiological models; proteins; CO2; Fahraeus effect; O2; O2-CO2 coupled transport; O2-Hb kinetics; cat brain microcirculation; gas transport; ischemia; microcirculation; multicompartmental model; vein; venules; Art; Biomedical engineering; Blood; Brain modeling; Equations; Ischemic pain; Kinetic theory; Predictive models; Steady-state; Veins;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
  • Conference_Location
    Montreal, Que.
  • Print_ISBN
    0-7803-2475-7
  • Type

    conf

  • DOI
    10.1109/IEMBS.1995.579800
  • Filename
    579800
    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=49&DC=3401925