Detection of TB antigens in liquid and vapor phases by an antibody-based piezoelectric biosensor

Author

Neuman, M.R. ; Perlak, S.C. ; Michalski, J.P. ; Bass, J.B., Jr. ; McCombs, C.C.

Author_Institution

Dept. of OB/GYN, Case Western Reserve Univ., Cleveland, OH, USA

Volume

2

fYear

1995

fDate

20-23 Sep 1995

Firstpage

1563

Abstract

The long-term objective of our research is to develop a rapid method for the diagnosis of tuberculosis and other infections caused by mycobacteria, using biosensor technology. The work presented here describes the construction of antibody-based piezoelectric crystals capable of detecting mycobacterial antigens in diluted cultures of attenuated M. tuberculosis, in an immunologically specific manner. The antigens were detected in either a liquid or vapor phase

Keywords

biomedical equipment; biosensors; patient diagnosis; piezoelectric transducers; TB antigen detection; antibody-based piezoelectric biosensor; antibody-based piezoelectric crystals; attenuated M. tuberculosis; diagnosis; diluted cultures; immunologically specific manner; infections; liquid phase; mycobacteria; tuberculosis; vapor phase; Biosensors; Bonding; Crystallization; Crystals; Electrodes; Gold; Immune system; Medical diagnostic imaging; Phase detection; Resonant frequency;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference

Conference_Location

Montreal, Que.

Print_ISBN

0-7803-2475-7

Type

conf

DOI

10.1109/IEMBS.1995.579829

Filename

579829