Title :
Detection of TB antigens in liquid and vapor phases by an antibody-based piezoelectric biosensor
Author :
Neuman, M.R. ; Perlak, S.C. ; Michalski, J.P. ; Bass, J.B., Jr. ; McCombs, C.C.
Author_Institution :
Dept. of OB/GYN, Case Western Reserve Univ., Cleveland, OH, USA
Abstract :
The long-term objective of our research is to develop a rapid method for the diagnosis of tuberculosis and other infections caused by mycobacteria, using biosensor technology. The work presented here describes the construction of antibody-based piezoelectric crystals capable of detecting mycobacterial antigens in diluted cultures of attenuated M. tuberculosis, in an immunologically specific manner. The antigens were detected in either a liquid or vapor phase
Keywords :
biomedical equipment; biosensors; patient diagnosis; piezoelectric transducers; TB antigen detection; antibody-based piezoelectric biosensor; antibody-based piezoelectric crystals; attenuated M. tuberculosis; diagnosis; diluted cultures; immunologically specific manner; infections; liquid phase; mycobacteria; tuberculosis; vapor phase; Biosensors; Bonding; Crystallization; Crystals; Electrodes; Gold; Immune system; Medical diagnostic imaging; Phase detection; Resonant frequency;
Conference_Titel :
Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-2475-7
DOI :
10.1109/IEMBS.1995.579829
