Anti-cancer effect of aloe emodin on breast cancer cells, MCF-7

Author

Amin, Indah Mohd ; Sheikh Abdul Kadir, Siti H. ; Rosdy, Nik Mohd Mazuan Nik Mohd ; Siran, Rosfaiizah ; Hasani, Narimah A. H.

Author_Institution

Inst. for Med. Mol. Biotechnol. (IMMB), Univ. Teknol. MARA (UiTM), Permatang Pauh, Malaysia

fYear

2013

fDate

23-25 Aug. 2013

Firstpage

103

Lastpage

108

Abstract

Phytochemicals of some plants are believed to have natural anti-proliferative properties to various cancer cells. Thus, they might have the potential as alternative choice for contemporary treatment as the latter are usually associated with many unpleasant side effects. The aim of this study is to investigate the possible anti-cancer effect of aloe emodin (AE; 1,8-Dihydroxy-3-hydro-xymethyl-anthraquinone) on estrogenpositive breast cancer cells, MCF-7. We were able to demonstrate the efficiency of AE, an antraquinone derivatives which are present in Aloe Vera leaves, in limiting the proliferation effect of MCF-7 cells in a dose and time dependent manner using WST-1 assay. Our preliminary result suggests that AE could be a promising natural candidate for future pharmacological study, targeting in breast cancer prevention strategies.

Keywords

biological organs; cancer; cellular biophysics; drugs; organic compounds; patient treatment; 1,8-dihydroxy-3-hydro-xymethyl-anthraquinone; Aloe Vera leave; MCF-7 cell proliferation; WST-1 assay; aloe emodin; anticancer effect; antiproliferative property; antraquinone derivative; breast cancer prevention strategy; cancer treatment; estrogenpositive breast cancer MCF-7 cell; pharmacological study; phytochemical; plant; Breast cancer; Cells (biology); Chemicals; Immune system; Media; Toxicology; Aloe Vera; WST-1; aloe emodin; anti-cancer; breast cancer MCF-7 cells;

fLanguage

English

Publisher

ieee

Conference_Titel

Systems Biology (ISB), 2013 7th International Conference on

Conference_Location

Huangshan

ISSN

2325-0704

Type

conf

DOI

10.1109/ISB.2013.6623802

Filename

6623802