DocumentCode
3404157
Title
Pendent chain linked delivery systems: from concept to practice
Author
Kulkarni, M.G.
Author_Institution
Div. of Chem. Eng., Nat. Chem. Lab., Pune, India
fYear
1996
fDate
29-31 Mar 1996
Firstpage
241
Lastpage
244
Abstract
Release of active ingredients from pendent chain linked hydrogels involves penetration of the medium, hydrolysis of the pendent link and diffusion of the active ingredient. Such systems would find practical applications only when the hydrolysis takes place at pH≃7. This was achieved by (a) using poly(N-vinyl imidazole) (PNVIm) as an enzyme mimicking polymer and (b) by incorporating imidazole groups in the vicinity of the ester link to be hydrolysed. These hydrogels would also serve as pH sensitive delivery systems
Keywords
biomedical equipment; gels; pH; patient treatment; polymers; active ingredient difusion; active ingredients release; enzyme mimicking polymer; ester link; hydrogels; hydrolysis; imidazole groups incorporation; pH sensitive delivery systems; pendent chain linked delivery systems; poly(N-vinyl imidazole); Anti-freeze; Biochemistry; Chemical engineering; Control systems; Ethanol; Laboratories; Lead; Methanol; Polymers; Testing;
fLanguage
English
Publisher
ieee
Conference_Titel
Biomedical Engineering Conference, 1996., Proceedings of the 1996 Fifteenth Southern
Conference_Location
Dayton, OH
Print_ISBN
0-7803-3131-1
Type
conf
DOI
10.1109/SBEC.1996.493160
Filename
493160
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