Title :
Interleukin-1β concentration in total knee arthroplasty
Author :
Kovacik, M.W. ; Gradisar, I.A. ; Sylvester, A.M. ; Haprian, J.J. ; Alexander, T.S.
Author_Institution :
Musculoskeletal Res. Lab., Summa Health Syst., Akron, OH
Abstract :
Interleukin-1β levels from synovial aspirates were examined to determine if they can be used as indicators of increased synovial activity and an inflammatory reaction within total knee arthroplasty. Synovial aspirates were obtained from nine knees scheduled for total knee arthroplasty and eleven knees scheduled for total knee revision. Using a high sensitivity ELISA test kit, the interleukin-1β concentrations were compared. A significant difference was found between the two knee groups. The knees scheduled for revision showed a higher concentration of interleukin-1β. Also, the knees scheduled for revision had a significantly higher volume of synovial fluid. This increased synovial activity in the revision knee group is most likely attributed to the high concentration of the particulate wear debris produced from the prosthesis
Keywords :
organic compounds; prosthetics; wear; high sensitivity ELISA test kit; inflammatory reaction; interleukin-1β concentration; knee surgery; particulate wear debris; synovial aspirates; synovial fluid volume; total knee arthroplasty; total knee revision; Biomembranes; Knee; Laboratories; Musculoskeletal system; Orthopedic surgery; Pathology; Plasma diagnostics; Prosthetics; Protocols; Testing;
Conference_Titel :
Biomedical Engineering Conference, 1996., Proceedings of the 1996 Fifteenth Southern
Conference_Location :
Dayton, OH
Print_ISBN :
0-7803-3131-1
DOI :
10.1109/SBEC.1996.493216
