Title :
A new hypothesis: inhibitory potentials of the gap-junctional intercellular communication play an important role in the tumorigenesis induced by biomaterials
Author :
Tsuchiya, T. ; Takahara, A. ; Cooper, S.L. ; Nakaoka, R. ; Degawa, H. ; Nakamura, A.
Author_Institution :
Div. of Med. Devices, Nat. Inst. of Health Sci., Tokyo, Japan
Abstract :
The authors propose a new hypothesis that the inhibitory potentials of intercellular communication play an important role in the tumorigenesis induced by various biomaterials. The authors´ study showed that the tumor-promoting activities of biomaterials were caused by some additives, some catalysts, the leachable oligomers and the surface interaction of cells and materials
Keywords :
cellular transport; prosthetics; additives; biomaterials; catalysts; gap-junctional intercellular communication; inhibitory potentials; intercellular communication; leachable oligomers; surface interaction; tumorigenesis; Additives; Biological materials; Chemical industry; Degradation; Implants; Neoplasms; Pigments; Polyethylene; Rats; Testing;
Conference_Titel :
Biomedical Engineering Conference, 1996., Proceedings of the 1996 Fifteenth Southern
Conference_Location :
Dayton, OH
Print_ISBN :
0-7803-3131-1
DOI :
10.1109/SBEC.1996.493217
