DNA microarray image analysis using active contour model

Major contributions of our approach include the followings: (1) We solve the problem of image rotation without manual adjustment. (2) The detection is robust with respect to irregular spot gaps. (3) Our approach is not affected by variations of color and size of spots. (4) Our approach performs well on different numbers of input channels. Besides, the proposed approach can not only handle multiple spots in microarray images, but also find more precise contours of spots. The approach is tested on microarray images obtained from the Stanford Microarray Database. Comprehensive experiments show highly encouraging results.