Title :
Microscopic image analysis in cervical cytology
Author :
Hause, L.L. ; Clowry, L.J. ; Megan, P.A.
Author_Institution :
Dept. of Pathol., Med. Coll. of Wisconsin, Milwaukee, WI, USA
Abstract :
Microscopic image analysis was used to quantify multiple cellular features in 54 cervical samples. Evaluation of the quantitative information was compared with the cytologic diagnosis of cervical smears. Measurements of deoxyribonucleic acid (DNA) in 14 dysplastic cases gave a skewed pattern for total DNA content per cell in intermediate cells and a significantly higher DNA content in cells classified as dysplastic. The intermediate cells in 8 normally diagnosed cases revealed a skew pattern for DNA distributions similar to dysplastic cases which suggests a risk group in the normal population. The quantitative information provided by microscopic image analysis assists cytologic diagnosis of cervical samples and may reduce diagnostic uncertainty.<>
Keywords :
DNA; cellular biophysics; computerised pattern recognition; computerised picture processing; medical computing; optical microscopy; patient diagnosis; DNA; cervical cytology; cervical smears; cytologic diagnosis; deoxyribonucleic acid; dysplastic cases; microscopic image analysis;
Conference_Titel :
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location :
New Orleans, LA, USA
Print_ISBN :
0-7803-0785-2
DOI :
10.1109/IEMBS.1988.94565
