Title :
Time dependent entropy analysis of multiunit activity in the cortex following the hypoxic-ischemic brain injury
Author :
Tong, Shanbao ; Ding, Ming Chieh ; Thakor, Nitish V.
Author_Institution :
Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA
Abstract :
Previous study has shown that the scalp electrical activity (e.g. EEG) could provide information on hypoxic-ischemic (HI) brain injury. The time dependent entropy (TDE) of EEG was applied as a means to segment the injury and recovery phases. A reduction in entropy during the injury was explained as the result of the spiking or bursting activity during the recovery of HI injury. The aim of this study is to investigate the spiking activity in the cortex during (HI) brain injury. The multiunit activity recorded from the cortex (CTX MUA) is analyzed with TDE methods. The spike sensitive TDE tracks the electric activity at the cellular level. The CTX MUA has high TDE value after the HI injury, which gradually returns to the baseline level as the brain recovers. This is the first report of cellular electrical response to global ischemic injury.
Keywords :
bioelectric potentials; brain models; cellular biophysics; electroencephalography; entropy; neurophysiology; EEG; asphyxia cardiac arrest; baseline level; bursting activity; cellular electrical response; cellular level; cortex; electric activity; entropy reduction; global ischemic injury; hypoxic-ischemic brain injury; injury phases; multiunit activity; recovery phases; scalp electrical activity; spiking activity; time dependent entropy analysis; Asphyxia; Biomedical engineering; Brain injuries; Electroencephalography; Entropy; Microelectrodes; Monitoring; Neurons; Neurophysiology; Scalp;
Conference_Titel :
Neural Engineering, 2003. Conference Proceedings. First International IEEE EMBS Conference on
Print_ISBN :
0-7803-7579-3
DOI :
10.1109/CNE.2003.1196837
