In vivo PET imaging of diabetic encephalopathy rat model

It is the study about the role of ¹⁸F-FDG PET imaging technology in differentiating diabetic encephalopathy (DE) rat model. 10 rats were injected with Streptozotocin to use as duplicate DE model rats, and 10 rats were injected with normal saline to use as control rats. The change of rat behavior was observed. HE staining was made to detect the intracerebral pathological changes in rats. In both groups, the conditions of intracerebral glucose metabolism in rats were observed in vivo through ¹⁸F-FDG PET imaging technology. Under PET imaging, glucose metabolism decreased in hippocampus in model group, and there were only mild neuron injury and slight glucose hypometabolism in control group. The combination of ¹⁸F-FDG PET imaging with behavioral and pathological observation could become one of ways to determine whether the model is successful.