Title :
A survey of recent work on evolutionary approaches to the protein folding problem
Author :
Greenwood, Garrison W. ; Shin, Jae-Min ; Lee, Byungkook ; Fogel, Gary B.
Author_Institution :
Dept. of Comput. Sci., Western Michigan Univ., Kalamazoo, MI, USA
Abstract :
A problem of immense importance in computational biology is the determination of the functional conformations of protein molecules. With the advent of faster computers, it is now possible to use rules to search conformation space for protein structures that have minimal free energy. The paper surveys work done in the last five years (1994-99) using evolutionary search algorithms to find low energy protein conformations. In particular, a detailed description is included of some work recently started at the National Cancer Institute, which uses evolution strategies
Keywords :
biology computing; evolutionary computation; molecular biophysics; proteins; search problems; computational biology; conformation space; evolution strategies; evolutionary approaches; evolutionary search algorithms; functional conformations; low energy protein conformations; minimal free energy; protein folding problem; protein molecules; protein structures; Amino acids; Biological systems; Cancer; Computational biology; Evolution (biology); Evolutionary computation; Laboratories; Proteins; Sequences; Shape;
Conference_Titel :
Evolutionary Computation, 1999. CEC 99. Proceedings of the 1999 Congress on
Conference_Location :
Washington, DC
Print_ISBN :
0-7803-5536-9
DOI :
10.1109/CEC.1999.781969
