Relaxation effect of total flavonoids from peanut hull on rat thoracic aorta

Author

Manli Xia ; Min Wang

Author_Institution

Dept. of Physiol., Jiaxing Univ., Jiaxing, China

fYear

2011

fDate

19-22 Aug. 2011

Firstpage

425

Lastpage

427

Abstract

Objective: To explore the vasoactive effect of total flavonoids from peanut hull (TFPH) on rat thoracic aortas and its potential mechanism. Methods: The tension of thoracic aortic rings isolated from male Sprague-Dawley rat was measured in the organ bath system. Results: 1. TFPH (20-640 mg/l) concentration-dependently induced vasorelaxation (P <; 0.01 vs. control) in aortas previously contracted by KCl or phenylephrine (PE) regardless of endothelium. 2. The EC50 (80 mg/l) concentration of TFPH reduced Ca²⁺-induced contraction (P <; 0.01 vs. control) in endothelium-denuded aortas preincubated with KCl or PE. Conclusion: The vasodilatation induced by total flavonoids from peanut hull may involve the inhibition of vascular smooth muscular voltage- and receptor-dependent Ca²⁺ channels.

Keywords

biological organs; biomedical materials; blood vessels; organic compounds; EC50 concentration; TFPH concentration; endothelium; endothelium-denuded aortas; male Sprague-Dawley rat; organ bath system; peanut hull; phenylephrine; rat thoracic aortas; thoracic aortic rings; total flavonoids; vascular smooth muscular receptor-dependent channel; vascular smooth muscular voltage-dependent channel; vasodilatation; vasorelaxation; Educational institutions; Erbium; Extracellular; Muscles; Physiology; Protocols; Public healthcare; aorta; peanut hull; total flavonoids; vasodilatation;

fLanguage

English

Publisher

ieee

Conference_Titel

Human Health and Biomedical Engineering (HHBE), 2011 International Conference on

Conference_Location

Jilin

Print_ISBN

978-1-61284-723-8

Type

conf

DOI

10.1109/HHBE.2011.6027990

Filename

6027990