A general model of cerebrovascular controls

Author

Belardinelli, Enzo ; Ursino, Mauro ; Di Gammarco, P.

Author_Institution

Dept. of Electron. Inf. & Syst. Sci., Bologna Univ., Italy

fYear

1988

fDate

4-7 Nov. 1988

Firstpage

525

Abstract

The main features of a mathematical model of cerebral-blood-flow regulation in the rat are discussed. In building the model, the actions of all the main feedback mechanisms (chemical, neurogenic, and myogenic), which are assumed to work on the cerebrovascular bed to regulate blood flow, are described according to present physiological knowledge. Simulation of blood flow based on the model allows the role played by the above mechanisms in response to different physiopathological stimuli to be determined. Several experimental conditions (reactive hyperemia autoregulation to arterial pressure changes, moderate arterial hypoxia, functional hyperemia, stimulation of nerve fibers) can be studied with the help of the model.<>

Keywords

brain models; haemodynamics; autoregulation; blood flow regulation; cerebral blood flow regulation; cerebrovascular bed; cerebrovascular controls; feedback mechanisms; functional hyperemia; mathematical model; moderate arterial hypoxia; nerve fibres stimulation; physiopathological stimuli; rat; reactive hyperemia;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE

Conference_Location

New Orleans, LA, USA

Print_ISBN

0-7803-0785-2

Type

conf

DOI

10.1109/IEMBS.1988.94641

Filename

94641