Title :
The role of SBHL in tumor growth and immune functions in mice
Author_Institution :
Dept. of Immunology, Beihua Univ., Jilin, China
Abstract :
To investigate the effects of solasodine hydrochloride (SBHL) on tumor growth and its anti-tumor immune response mechanisms. Methods: S180, tumor-bearing mice were treated by intraperitoneal injection of SBHL [10, 30, 50 mg / (kg.d)], after a continuous injection of 14 days, tumor growth and the effects of SBHL on immune functions were observed. Results : SBHL significantly inhibited the growth of S180 sarcoma, positively regulated the inhibited immune function of S180, also promoted the lymphocyte proliferation and increased IL-2 production capacity and enhanced NK and LAK cell activity. Conclusion : These results suggested that SBHL can inhibit tumor growth; the immune enhancement effects of SBHL may exert its anti-tumor effects of an important way.
Keywords :
biomedical materials; blood; cancer; cellular biophysics; organic compounds; tumours; IL-2 production capacity; LAK cell activity; NK cell activity; S180 sarcoma; SBHL; antitumor immune response mechanism; immune function; intraperitoneal injection; lymphocyte proliferation; solasodine hydrochloride; tumor growth; tumor-bearing mice; Cells (biology); Educational institutions; Immune system; Mice; Suspensions; Tumors; IL-2; LAK activity; NK activity; Tumor-bearing mice; solasodine hydrochloride;
Conference_Titel :
Human Health and Biomedical Engineering (HHBE), 2011 International Conference on
Conference_Location :
Jilin
Print_ISBN :
978-1-61284-723-8
DOI :
10.1109/HHBE.2011.6028362
