Title :
Protective effects of puerarin solution on alcohol encephalopathy hippocampus
Author :
Wen-bo Ju ; Zhi-wei Qu ; Wei-gao Shen
Author_Institution :
Beihua Univ., Jilin, China
Abstract :
To examine the effects of Puerarin solution on alcohol-induced injuries in hippocampus. Thirty Wistar rats were divided into control group, model group and puerarin group. After 30 days, the Endotoxin (ET) levels in plasma and TNF-α in cerebral tissue were measured. Pathological changes in cerebral tissue were observed by light microscope. ET and TNF-α in the model group were significantly higher than those in the control group (p<;0.05); ET and TNF-α in puerarin group was slightly higher than those in the control group and significantly lower than those in the model group (p<;0.01); Mild pathological changes in hippocampus of model group, no obvious pathological changes in the other groups. The protective effects of puerarin may be related to its inhibition of ET and TNF-α production.
Keywords :
biological tissues; biomedical materials; brain; cellular biophysics; diseases; injuries; neurophysiology; optical microscopy; organic compounds; TNF-α production; alcohol encephalopathy hippocampus; alcohol-induced injuries; cerebral tissue; endotoxin levels; light microscopy; mild pathological changes; protective effects; puerarin solution; Blood; Brain modeling; Hippocampus; Liver; Plasmas; Rats; Alcohol; Puerarin; encephalopathy; hippocampus; plasma endotoxin (ET);
Conference_Titel :
Human Health and Biomedical Engineering (HHBE), 2011 International Conference on
Conference_Location :
Jilin
Print_ISBN :
978-1-61284-723-8
DOI :
10.1109/HHBE.2011.6028385
