Title :
A biodegradable nanofiber by electrospinning and its cytocompatibility of polymer-coated sirolimus-eluting stents with cardiac muscle cell
Author :
Han Hai-ling ; Sun Yu-qin ; Song Wen-gang
Author_Institution :
Dept. of Cardiology & Brain, Beihua Univ., Jilin, China
Abstract :
Ultrafine fibers composed of poly (ethyleneglycol)-poly (l-lactic acid) (PEG-PLA) diblock copolymer matrix were prepared by electrostatic fiber spinning and which have good applied foreground in constructing tissue engineering scaffold materials. By this process, polymer fibers with diameters from 300 nm to 1 Am the nanometer range. The Cytocompatibility of the PEG-PLLA fibers against cardiac muscle cell was evaluated by MTT method and FCM. The results showed that, in terms of cytocompatibility, PEG-PLA is promising biomaterials for cardiac tissue engineering and other biomedical applications.
Keywords :
biodegradable materials; biomedical materials; cardiology; cellular biophysics; electrospinning; muscle; nanobiotechnology; nanofibres; polymer blends; polymer fibres; tissue engineering; biodegradable nanofiber; cardiac muscle cell; cardiac tissue engineering; cytocompatibility; diblock copolymer matrix; electrospinning; electrostatic fiber spinning; poly(ethyleneglycoI)-poly (1-lactic acid); polymer fibers; polymer-coated sirolimus-eluting stents; tissue engineering scaffold materials; ultraflne fibers; Electricity; Nanobioscience; Polymers; Programmable logic arrays; Spinning; Textile fibers; Cytocompatibility; Electrostatic fiber spinning; PEG-PLLA; cardiac muscle cell;
Conference_Titel :
Human Health and Biomedical Engineering (HHBE), 2011 International Conference on
Conference_Location :
Jilin
Print_ISBN :
978-1-61284-723-8
DOI :
10.1109/HHBE.2011.6028387
