The feature of resonance of gene expression and identification of the genes associated with Alzheimer´s disease

Alzheimer´s disease (AD) is the most common type of dementia and the amount of risk of AD that is attributable to genetics is estimated to be around 70%. Since 2000, cDNA microarray technology is used to identify AD-related gene (ADG), and the commonly used criterion of identification is the up-regulation or down-regulation of genes. In this paper, the following feature named resonance of gene expression is observed from gene expression profile of AD: Some genes change their expression levels synchronously with a given ADG at uncontrolled stage while their expressions are independent to the ADG at control stage. This feature likes the resonance of wave or the synchronization of a group of dancers. The genes holding this feature are related to AD potentially and are identified as the candidate ADGs. The shown characteristic at Fig.1 is suggested with the result o f famous Prof. Goate´s group on Feb. 2012.