Title :
Deep brain stimulation may reduce tremor by preferential blockade of slower axons via antidromic activation
Author :
García, Míriam R. ; Verwoerd, Mark ; Pearlmutter, Barak A. ; Wellstead, Peter E. ; Middleton, Richard H.
Author_Institution :
NUIM, Ireland
Abstract :
Deep brain stimulation (DBS) has been used to ameliorate essential and Parkinsonian tremor, however the detailed mechanism by which tremor reduction is achieved remains unclear. We hypothesize that DBS works by reducing time delays in the feedback paths of the motor control loops. In particular, we suggest that antidromic activation of axonal pathways induced by stimulation will preferentially block axons with longer propagation times, reducing time delays in neuronal motor circuits in a stabilising manner. We demonstrate the plausibility of this hypothesis using two simple computational models which account for a variety of experimental results, and allow us to makes a number of testable predictions.
Keywords :
Biological system modeling; Delay; Joining processes; Mathematical model; Nerve fibers; Oscillators; Satellite broadcasting;
Conference_Titel :
Decision and Control and European Control Conference (CDC-ECC), 2011 50th IEEE Conference on
Conference_Location :
Orlando, FL, USA
Print_ISBN :
978-1-61284-800-6
Electronic_ISBN :
0743-1546
DOI :
10.1109/CDC.2011.6160710