VEGF-C, VEGF-D, and VEGFR-3 and their roles in lymphatic metastasis of tumors

Author

Jian Wang ; Shi-Qian Zhang

Author_Institution

Dept. of Gynaecology & Obstetrics, Tengzhou Maternal & Children´s Hosp., Tengzhou, China

fYear

2011

fDate

19-22 Aug. 2011

Firstpage

977

Lastpage

980

Abstract

Lymphatic metastasis is one of the critical metastatic routes of malignant tumors, and the involvement of lymph nodes is usually one of the key predictors of prognosis. In recent years, studies on animal models and clinical studies have suggested that vascular endothelial growth factor (VEGF)-C/VEGF-D/VEGF receptor-3 (VEGFR-3) signaling system plays important roles in the process of lymphatic metastasis of tumors. In this article, we have reviewed the recent advances in research on the roles and mechanisms of VEGF-C/VEGF-D/VEGFR-3 signaling system in lymphatic metastasis of tumors.

Keywords

biological organs; cellular biophysics; molecular biophysics; proteins; tumours; VEGF signaling system; VEGF-C; VEGF-D; VEGFR-3; VEGR signaling system; lymph nodes; malignant tumors; tumor lymphatic metastasis; vascular endothelial growth factor; vascular endothelial growth receptor; Humans; Lymph nodes; Metastasis; Mice; Proteins; Tumors; lymphangiogenesis; lymphatic metastasis; tumor; vascular endothelial growth factor (VEGF);

fLanguage

English

Publisher

ieee

Conference_Titel

Human Health and Biomedical Engineering (HHBE), 2011 International Conference on

Conference_Location

Jilin

Print_ISBN

978-1-61284-723-8

Type

conf

DOI

10.1109/HHBE.2011.6028987

Filename

6028987