Title :
A mechanical model to simulate uptake and elimination of inhalation anesthetics
Author :
Loughlin, Patrick J. ; Bowes, Watson A. ; Westenskow, Dwayne R.
Author_Institution :
Dept. of Anesthesiology, Utah Univ., Salt Lake City, UT, USA
Abstract :
Using olive oil to simulate body tissues, a mechanical model of uptake and elimination of inhalation anesthetics was developed. Body tissues were grouped according to anesthetic solubility and blood perfusion, and modeled with equivalent oil volumes. Changes in cardiac output were simulated by varying gas flows through the oil chambers. Alveolar ventilation was augmented by adjusting the minute ventilation setting of the ventilator. During 64 minutes of uptake and washout, the mechanical model end-tidal halothane concentration remained within 0.07 vol.% of a computer simulation. The model may prove useful in developing and testing anesthesia equipment without the need for animal experiments or human volunteers.<>
Keywords :
cardiology; physiological models; pneumodynamics; 64 min; alveolar ventilation; anesthesia equipment; anesthetic solubility; blood perfusion; body tissues; cardiac output; end-tidal halothane concentration; equivalent oil volumes; gas flows; inhalation anesthetics; mechanical model; minute ventilation setting; oil chambers; olive oil; uptake elimination; uptake simulation; ventilator; washout;
Conference_Titel :
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location :
New Orleans, LA, USA
Print_ISBN :
0-7803-0785-2
DOI :
10.1109/IEMBS.1988.94735