Study of Rats´ Mammary Precancer models-induced by DMBA combined estrogen and progesterone

Author

Min Ma ; Dehui Li ; Guijuan Zhang ; Rui Liao ; Bizhu Tan

Author_Institution

Dept. of Traditional Chinese Med., Jinan Univ., Guangzhou, China

fYear

2011

fDate

19-22 Aug. 2011

Firstpage

1292

Lastpage

1295

Abstract

Objective: To explore using 7, 12-Dimethylbenz[a] anthracen(DMBA) combined estrogen and progesterone induce Rats Model of Mammary Precancer, and investigate the inhibitory effect of tamoxifen ointment. Methods: 30 virginal female SD rats were randomly allocated into three groups, A: Blank control group (10); B: DMBA+hormones group (10); C: TAM group (10). The general morphology and pathology were observed when the rats were executed after 60 days. Results: The incidence of premalignant breast disease in model group B was 87.5%, while group C was 47.5%. Group B was significantly higher than group C (P<;0.01). Conclusion: DMBA+hormones method is a method to establish Rats Model of Mammary Precancer. Tamoxifen could effectively prevent the occurrence of DMBA+hormones induced breast precancer in rats.

Keywords

biological tissues; biomedical measurement; cancer; drugs; organic compounds; 7,12-dimethylbenzanthracen; DMBA induced mammary precancer; estrogen; premalignant breast disease; progesterone; rat mammary precancer models; tamoxifen ointment; Breast tumors; Cancer; Lesions; Rats; DMBA; animal model; estrogen; mammary precancerous lesion; pathology; progesterone; tamoxifen;

fLanguage

English

Publisher

ieee

Conference_Titel

Human Health and Biomedical Engineering (HHBE), 2011 International Conference on

Conference_Location

Jilin

Print_ISBN

978-1-61284-723-8

Type

conf

DOI

10.1109/HHBE.2011.6029068

Filename

6029068