Understanding centrality-lethality rule in yeast Protein-Protein Interaction network by topological property

Author

Dong Yun-Yuan ; Wang Zheng-Hua ; Liu Qi-Jun ; Yong-xian, Wang

Author_Institution

Sch. of Comput., Nat. Univ. of Defense Technol., Changsha, China

Volume

2

fYear

2011

fDate

20-22 Aug. 2011

Firstpage

116

Lastpage

118

Abstract

One of the most important problems in biology is to discover the relationship between topological properties and functional features of proteins in Protein-Protein Interaction (PPI) network. The centrality-lethality rule reveals that hub proteins tend to be more essential than non-hub proteins. Why hub proteins tend to be more essential? Here, we classified hub proteins into two types: essential hub and nonessential hub. We found that essential hubs are more important to the survival of the cell and they can be called intra-modular hubs while nonessential hubs tend to be inter-modular hubs.

Keywords

biology computing; cellular biophysics; microorganisms; molecular biophysics; molecular configurations; pattern classification; proteins; biology; centrality-lethality rule; database; hub protein classification; inter-modular hub; intra-modular hub; nonessential hub protein; nonhub protein; protein functional feature; topological property; yeast protein-protein interaction network; Bioinformatics; Color; Correlation; Educational institutions; Genomics; Proteins; centrality; essential hub; nonessential hub; protein-protein interaction network;

fLanguage

English

Publisher

ieee

Conference_Titel

Information Technology and Artificial Intelligence Conference (ITAIC), 2011 6th IEEE Joint International

Conference_Location

Chongqing

Print_ISBN

978-1-4244-8622-9

Type

conf

DOI

10.1109/ITAIC.2011.6030289

Filename

6030289