Multifunctional lab-on-a-tube (LOT) probe for simultaneous neurochemical and electrophysiological activity measurements

Author

Li, Cong ; Wu, P.M. ; Prince, S.J. ; Wu, Zhisheng ; Chakraborti, S. ; Ahn, Chong H. ; Hartings, J.A. ; Narayan, R.K.

Author_Institution

Cushing Neuromonitoring Lab., Feinstein Inst. for Med. Res., New York, NY, USA

fYear

2013

fDate

16-20 June 2013

Firstpage

880

Lastpage

883

Abstract

A multifunctional lab-on-a-tube (LOT) probe for simultaneous in vivo neurochemical and electrophysiological activity measurements is presented. Developed heterostructured platinum/iridium oxide (Pt/IrOx) microelectrodes have shown a superior signal-to-noise ratio and around 80 times slower polarization rate than platinum microelectrodes with the same surface area. Oxygen and glucose biosensors have been integrated to simultaneously detect their changes during cortical spreading depolarizations. The developed LOT shows minimum electrode crosstalk under optimized electrode design and placement, so it can improve the determination of cortical spreading depolarization causing brain injury with respect to multiple cerebral metabolic biomarkers.

Keywords

bioelectric potentials; biomedical electrodes; biosensors; brain; electrochemical sensors; iridium compounds; microelectrodes; neurophysiology; oxygen; patient diagnosis; platinum; sugar; LOT probe; O; Pt-IrO_x; brain injury; cerebral metabolic biomarker; cortical spreading depolarization; electrophysiological activity measurement; glucose biosensor; heterostructured microelectrode; in vivo measurement; multifunctional lab-on-a-tube probe; neurochemical activity measurement; optimized electrode design; oxygen sensor; Biosensors; Microelectrodes; Oxygen; Probes; Sugar; Neurochemical; electroencephalography; lab-on-a-tube; spreading depolarization;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII), 2013 Transducers & Eurosensors XXVII: The 17th International Conference on

Conference_Location

Barcelona

Type

conf

DOI

10.1109/Transducers.2013.6626908

Filename

6626908