High-speed chemical imaging inside a microfluidic channel

In this study, a high-speed chemical imaging system was developed for visualization of the interior of a microfluidic channel. The chemical imaging system is based on the principle of the light-addressable potentiometric sensor (LAPS), which is a semiconductor-based chemical sensor. Measurement of ion concentrations can be carried out in parallel at up to 64 points on the sensor surface, illuminated by optical fibers. A microfluidic channel was constructed on the sensor surface and the temporal change of pH distribution inside the microfluidic channel was recorded at a maximum rate of 100 frames per second (fps).