Embryo lab chip taking advantage of microfluidics and cell co-culturing

Author

Cheng-Hsien Liu ; Kuo-Wei Chang ; Pei-Yu Chang ; Yi-Jung Sung ; Hong-Yuan Huang ; Da-Jeng Yao ; Shih-Kang Fan ; Wensyang Hsu ; Chin-Jung Li

Author_Institution

Dept. of Power Mech. Eng., Nat. Tsing Hua Univ., Hsinchu, Taiwan

fYear

2015

fDate

21-25 June 2015

Firstpage

638

Lastpage

641

Abstract

This research serves as an in vitro platform for fertilization and embryonic development. Thin polydimethylsiloxane (PDMS) membrane was etched to create an array of through-holes, and sandwiched between two PDMS channels to form an upper chamber and lower chamber. This device integrates the concentration gradient design and perfusion system for proposed embryo coculture with stromal cells.

Keywords

bioMEMS; biomedical equipment; cellular biophysics; etching; haemorheology; lab-on-a-chip; membranes; microfluidics; polymers; PDMS channels; cell coculturing; concentration gradient design; embryo coculture; embryo lab chip; embryonic development; etching; fertilization; in vitro platform; microfluidics; perfusion system; stromal cells; thin polydimethylsiloxane membrane; through-hole array; Biomembranes; Embryo; In vivo; MIMICs; Mechanical engineering; Microfluidics; Simulation; Embryo Culture; Perfusion System; Porous Membrane; Three Dimensional Biomimetic Microsystem;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2015 Transducers - 2015 18th International Conference on

Conference_Location

Anchorage, AK

Type

conf

DOI

10.1109/TRANSDUCERS.2015.7181004

Filename

7181004