Capturing cellular communication with guided electrode network on a silicon integrated circuit chip

This paper describes the development of a multi-electrode array (MEA) with guided network for cell-to-cell communication transduction using a standard integrated circuit (IC) fabrication process. Unlike conventional electronic system, bio-system requires a special handling environment that is uncommon in conventional IC technology. The work presented here demonstrated the interaction between electrically active cells such as neuron and cardiac cells and an IC based system. Through a carefully designed array, and ionic action of a cell, extracellular signals can be captured and imaged