Title :
Laminar flow induces endothelial cell growth arrest through p53 phosphorylation and stabilization
Author :
Chen, Benjamin ; Yuan, Suli ; Hsu, Pin-Pin ; Shyy, John Y -J ; Chien, Shu
Author_Institution :
Dept. of Bioeng., California Univ., San Diego, La Jolla, CA, USA
Abstract :
We investigated the role of p53 in mediating the laminar flow-induced growth arrest in endothelial cells (ECs). c-Jun N-terminal kinase (JNK) activity induced by laminar flow is able to phosphorylate p53, an event which leads to the stabilization of p53. We also found that laminar flow caused an increase in the protein level of the exogenous HA-p53 in ECs. This increased p53 level would suppress EC proliferation
Keywords :
biochemistry; blood vessels; cellular biophysics; genetics; haemodynamics; proteins; c-Jun N-terminal kinase activity; endothelial cell growth arrest; exogenous HA-p53; gene product; laminar flow-induced growth arrest; p53 phosphorylation; p53 stabilization; protein level; tumor suppressor; Biomedical engineering; Bovine; DNA; Electrokinetics; Immune system; Neoplasms; Presence network agents; Proteins; Stress control; Visualization;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802025
