Title :
The response of lung epithelial cells to transmural pressure
Author :
Bilek, Anastacia M. ; Dee, Kay C. ; Gaver, Donald P.
Author_Institution :
Dept. of Biomed. Eng., Tulane Univ., New Orleans, LA, USA
Abstract :
Understanding the mechanisms of injury in respiratory distress syndrome may improve treatment methods. We hypothesize that mechanical stresses associated with airway reopening may contribute to the pathology of RDS by altering the biochemical activities of the epithelium. We found that L2 cells produce mitogens and/or other compounds in vitro, which stimulate fibroblast proliferation when exposed to a short static transmural pressure but not oscillatory pressures
Keywords :
biochemistry; cellular biophysics; lung; paediatrics; pneumodynamics; L2 cells; airway reopening; biochemical activities; fibroblast proliferation; injury mechanisms; lung epithelial cells; mechanical stresses; mitogens; premature infants; respiratory distress syndrome; short static pressure; transmural pressure response; Cells (biology); Compressive stress; Fibroblasts; In vitro; Injuries; Lungs; Medical treatment; Pathology; Pediatrics; Ventilation;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802051
