Title :
Mechanico-transduction through selectins signals integrin mediated neutrophil arrest under shear flow
Author :
Simon, Scott I. ; Hu, Yu ; Smith, C. Wayne
Author_Institution :
Speros Martel Sect. of Leukocyte Biol., Baylor Coll. of Med., Houston, TX, USA
Abstract :
Evidence is provided for activation of neutrophils rolling on E-selectin, independent of signaling through G-proteins. A cooperative mechanism in which L-selectin and PSGL-1 were required for optimal activation was found. Neutrophil emigration appears to be regulated by shear and signals transduced through selectins during tethering and rolling
Keywords :
adhesion; biochemistry; blood vessels; cellular biophysics; haemorheology; proteins; L-selectin; PSGL-1; activation of neutrophils; binding; cooperative mechanism; integrin mediated neutrophil arrest; mechanico-transduction; neutrophil emigration; optimal activation; rolling; rolling on E-selectin; shear flow; tethering; Adhesives; Cells (biology); Educational institutions; Hydrodynamics; Stress; Velocity measurement; White blood cells;
Conference_Titel :
[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint
Conference_Location :
Atlanta, GA
Print_ISBN :
0-7803-5674-8
DOI :
10.1109/IEMBS.1999.802083
