Molecular mechanisms of platelet-tumor cell adhesion under flow

Author

McCarty, Owen ; Konstantopoulos, Konstantinos

Author_Institution

Dept. of Chem. Eng., Johns Hopkins Univ., Baltimore, MD, USA

Volume

1

fYear

1999

fDate

1999

Abstract

The ability of tumor cells to interact with platelets constitutes an indispensable determinant in the success of metastatic spread. This study was undertaken to investigate the sequence of molecular events mediating human colon (LS174T) carcinoma cell adhesion to surface adherent platelets under flow. A two-step process of tumor cell recruitment has been elucidated, involving LS174T tethering mediated primarily by platelet P-selectin, and subsequent arrest via platelet α_IIbβ₃. This cascade of events depicts an efficacious process for colon carcinoma arrest at sites of vascular injury

Keywords

adhesion; cellular biophysics; haemodynamics; haemorheology; molecular biophysics; proteins; tumours; LS174T tethering; carcinoma arrest; flow conditions; human colon carcinoma cell; metastatic spread; molecular mechanisms; platelet α_IIbβ₃; platelet P-selectin; platelet-tumor cell adhesion; surface adherent platelets; tumor cell recruitment; two-step process; vascular injury sites; Adhesives; Colon; Event detection; Humans; In vitro; Metastasis; Neoplasms; Plasmas; Stress; Tumors;

fLanguage

English

Publisher

ieee

Conference_Titel

[Engineering in Medicine and Biology, 1999. 21st Annual Conference and the 1999 Annual Fall Meetring of the Biomedical Engineering Society] BMES/EMBS Conference, 1999. Proceedings of the First Joint

Conference_Location

Atlanta, GA

ISSN

1094-687X

Print_ISBN

0-7803-5674-8

Type

conf

DOI

10.1109/IEMBS.1999.802096

Filename

802096